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The crown-of-thorns starfish genome as a guide for biocontrol of this coral reef pest

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dc.contributor Dna Sequencing Sect
dc.contributor Sch Biol Sci
dc.contributor Cape Ferguson
dc.contributor University Of Alabama System
dc.contributor Marine Genom Unit
dc.contributor Univ Queensland
dc.contributor Australian Inst Marine Sci
dc.contributor Australian Institute Of Marine Science
dc.contributor Ctr Marine Sci
dc.contributor Alabama Museum Nat Hist
dc.contributor Okinawa Inst Sci & Technol
dc.contributor Grad Univ
dc.contributor Dept Biol Sci
dc.contributor Lab Nacl Genom Biodiversidad
dc.contributor University Of The Sunshine Coast
dc.contributor Ctr Invest & Estud Avanzados Ipn Irapuato
dc.contributor University Of Alabama Tuscaloosa
dc.contributor Univ Alabama
dc.contributor Conacyt
dc.contributor Univ Sunshine Coast
dc.contributor Inst Sci & Technol
dc.contributor Genecol Res Ctr
dc.contributor University Of Queensland
dc.contributor Okinawa Institute Of Science & Technology Graduate University
dc.contributor.author BAUGHMAN, KENNETH W.
dc.contributor.author GAUTHIER, MARIE E. A.
dc.contributor.author MCDOUGALL, CARMEL
dc.contributor.author WANG, TIANFANG
dc.contributor.author BOSE, UTPAL
dc.contributor.author HISATA, KANAKO
dc.contributor.author CUMMINS, SCOTT F.
dc.contributor.author DEGNAN, BERNARD M.
dc.contributor.author HALL, MICHAEL R.
dc.contributor.author KOCOT, KEVIN M.
dc.contributor.author FERNANDEZ-VALVERDE, SELENE L.
dc.contributor.author HATLEBERG, WILLIAM L. .
dc.contributor.author KRISHNAN, ARUNKUMAR
dc.contributor.author MOTTI, CHERIE A.
dc.contributor.author SHOGUCHI, EIICHI
dc.contributor.author XIANG, XUEYAN
dc.contributor.author ZHAO, MIN
dc.contributor.author SHINZATO, CHUYA
dc.contributor.author FUJIE, MANABU
dc.contributor.author KANDA, MIYUKI
dc.contributor.author SATOH, NORIYUKI
dc.contributor.author DEGNAN, SANDIE M.
dc.date.accessioned 2017-06-08T01:08:53Z
dc.date.accessioned 2017-06-08T01:08:53Z
dc.date.accessioned 2019-07-08T02:14:22Z
dc.date.available 2017-06-08T01:08:53Z
dc.date.available 2017-06-08T01:08:53Z
dc.date.available 2019-07-08T02:14:22Z
dc.date.issued 2017-04-13
dc.identifier.citation Hall MR, Kocot KM, Baughman KW, Fernandez-Valverde SL, Gauthier MEA, Hatleberg WL, Krishnan A, McDougall C, Motti CA, Shoguchi E, Wang TF, Xiang XY, Zhao M, Bose U, Shinzato C, Hisata K, Fujie M, Kanda M, Cummins SF, Satoh N, Degnan SM, Degnan BM (2017) The crown-of-thorns starfish genome as a guide for biocontrol of this coral reef pest. Nature 544: 231-234
dc.identifier.issn 0028-0836
dc.identifier.uri http://epubs.aims.gov.au/11068/10102
dc.description.abstract The crown-of-thorns starfish (COTS, the Acanthaster planci species group) is a highly fecund predator of reef-building corals throughout the Indo-Pacific region(1). COTS population outbreaks cause substantial loss of coral cover, diminishing the integrity and resilience of reef ecosystems(2-6). Here we sequenced genomes of COTS from the Great Barrier Reef, Australia and Okinawa, Japan to identify gene products that underlie species-specific communication and could potentially be used in biocontrol strategies. We focused on water-borne chemical plumes released from aggregating COTS, which make the normally sedentary starfish become highly active. Peptide sequences detected in these plumes by mass spectrometry are encoded in the COTS genome and expressed in external tissues. The exoproteome released by aggregating COTS consists largely of signalling factors and hydrolytic enzymes, and includes an expanded and rapidly evolving set of starfish-specific ependymin-related proteins. These secreted proteins may be detected by members of a large family of olfactory-receptor-like G-protein-coupled receptors that are expressed externally, sometimes in a sex-specific manner. This study provides insights into COTS-specific communication that may guide the generation of peptide mimetics for use on reefs with COTS outbreaks.
dc.description.sponsorship We thank R. C. Wyeth for assistance in behavioural and statistical analyses, and P. Thomas-Hall for assistance in COTS husbandry. This study was supported by funds from the Australian Research Council (B.M.D. and S.M.D.), the Australian Government Department of Environment Reef Rescue Program (M.R.H. and S.F.C.), and internal funds of OIST for Marine Genomics Unit (N.S.). K.M.K. was funded by a NSF International Postdoctoral Research Fellowship.
dc.language English
dc.subject Science & Technology - Other Topics
dc.subject Transmembrane Topology
dc.subject Multidisciplinary Sciences
dc.subject Acanthaster-planci
dc.subject Tandem Mass-spectrometry
dc.subject Hidden Markov Model
dc.subject Phylogenomic Resolution
dc.subject Read Alignment
dc.subject Gpcr Repertoire
dc.subject Multiple Sequence Alignment
dc.subject Receptor Genes
dc.subject Identification
dc.title The crown-of-thorns starfish genome as a guide for biocontrol of this coral reef pest
dc.type journal article
dc.identifier.doi 10.1038/nature22033
dc.identifier.wos WOS:000398897900037


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