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Intraspecific differences in molecular stress responses and coral pathobiome contribute to mortality under bacterial challenge in Acropora millepora

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dc.contributor Australian Institute Of Marine Science
dc.contributor Univ Texas Austin
dc.contributor University Of Texas Austin
dc.contributor Australian Inst Marine Sci
dc.contributor Dept Integrat Biol
dc.contributor University Of Texas System
dc.contributor.author MATZ, MIKHAIL V.
dc.contributor.author WRIGHT, RACHEL M.
dc.contributor.author KENKEL, CARLY D.
dc.contributor.author DUNN, CARLY E.
dc.contributor.author SHILLING, ERIN N.
dc.contributor.author BAY, LINE K.
dc.date.accessioned 2017-07-20T22:30:57Z
dc.date.accessioned 2017-07-20T22:30:57Z
dc.date.accessioned 2019-05-09T01:15:36Z
dc.date.available 2017-07-20T22:30:57Z
dc.date.available 2017-07-20T22:30:57Z
dc.date.available 2019-05-09T01:15:36Z
dc.date.issued 2017-06-01
dc.identifier.citation Wright RM, Kenkel CD, Dunn CE, Shilling EN, Bay LK, Matz MV (2017) Intraspecific differences in molecular stress responses and coral pathobiome contribute to mortality under bacterial challenge in Acropora millepora. Scientific Reports 7: 2609
dc.identifier.issn 2045-2322
dc.identifier.uri http://epubs.aims.gov.au/11068/10482
dc.description.abstract Disease causes significant coral mortality worldwide; however, factors responsible for intraspecific variation in disease resistance remain unclear. We exposed fragments of eight Acropora millepora colonies (genotypes) to putatively pathogenic bacteria (Vibrio spp.). Genotypes varied from zero to >90% mortality, with bacterial challenge increasing average mortality rates 4-6 fold and shifting the microbiome in favor of stress-associated taxa. Constitutive immunity and subsequent immune and transcriptomic responses to the challenge were more prominent in high-mortality individuals, whereas low-mortality corals remained largely unaffected and maintained expression signatures of a healthier condition (i.e., did not launch a large stress response). Our results suggest that lesions appeared due to changes in the coral pathobiome (multiple bacterial species associated with disease) and general health deterioration after the biotic disturbance, rather than the direct activity of any specific pathogen. If diseases in nature arise because of weaknesses in holobiont physiology, instead of the virulence of any single etiological agent, environmental stressors compromising coral condition might play a larger role in disease outbreaks than is currently thought. To facilitate the diagnosis of compromised individuals, we developed and independently cross-validated a biomarker assay to predict mortality based on genes whose expression in asymptomatic individuals coincides with mortality rates.
dc.description.sponsorship We thank David Bourne for providing bacterial cultures and advice. Bioinformatic analyses were completed using Texas Advanced Computing Center resources. This study was supported by the Australian Institute of Marine Science to L.K.B. and NSF (DEB-1054766) to M.V.M. Travel support from the Center for Computational Biology and Bioinformatics at UT Austin was awarded to R.M.W. Two University Co-Operative Undergraduate Research Fellowships were awarded to E.N.S. and C.E.D.
dc.language English
dc.subject Pocillopora-damicornis
dc.subject Indo-pacific
dc.subject Science & Technology - Other Topics
dc.subject Vibrio-coralliilyticus
dc.subject Yellow Band Disease
dc.subject Innate Immunity
dc.subject Orbicella-faveolata
dc.subject Multidisciplinary Sciences
dc.subject Reef-building Corals
dc.subject White Syndrome
dc.subject Montastraea-faveolata
dc.subject Gene-expression
dc.title Intraspecific differences in molecular stress responses and coral pathobiome contribute to mortality under bacterial challenge in Acropora millepora
dc.type journal article
dc.identifier.doi 10.1038/s41598-017-02685-1
dc.identifier.wos WOS:000402508300020


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