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Role of gene body methylation in acclimatization and adaptation in a basal metazoan

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dc.contributor University Of Texas System
dc.contributor Univ Texas Austin
dc.contributor Australian Inst Marine Sci
dc.contributor Dept Integrat Biol
dc.contributor Australian Institute Of Marine Science
dc.contributor University Of Texas Austin MATZ, MIKHAIL V. DIXON, GROVES BAY, LINE K. LIAO, YI 2019-01-20T18:25:07Z 2019-01-20T18:25:07Z 2019-07-08T02:34:57Z 2019-01-20T18:25:07Z 2019-01-20T18:25:07Z 2019-07-08T02:34:57Z 2018-12-26
dc.identifier.citation Dixon G, Liao Y, Bay LK, Matz MV (2018) Role of gene body methylation in acclimatization and adaptation in a basal metazoan. Proceedings of the National Academy of Sciences of the United States of America 115(52): 13342-13346
dc.identifier.issn 0027-8424
dc.description.abstract Gene body methylation (GBM) has been hypothesized to modulate responses to environmental change, including transgenerational plasticity, but the evidence thus far has been lacking. Here we show that coral fragments reciprocally transplanted between two distant reefs respond predominantly by increase or decrease in genome-wide GBM disparity: The range of methylation levels between lowly and highly methylated genes becomes either wider or narrower. Remarkably, at a broad functional level this simple adjustment correlated very well with gene expression change, reflecting a shifting balance between expressions of environmentally responsive and housekeeping genes. In our experiment, corals in a lower-quality habitat up-regulated genes involved in environmental responses, while corals in a higher-quality habitat invested more in housekeeping genes. Transplanted fragments showing closer GBM match to local corals attained higher fitness characteristics, which supports GBM's role in acclimatization. Fixed differences in GBM between populations did not align with plastic GBM changes and were mostly observed in genes with elevated FST, which suggests that they arose predominantly through genetic divergence. However, we cannot completely rule out transgenerational inheritance of acquired GBM states.
dc.language English
dc.subject Reciprocal
dc.subject Intragenic Dna Methylation
dc.subject Dna Methylation
dc.subject Fitness
dc.subject Science & Technology - Other Topics
dc.subject Genome
dc.subject Epigenetics
dc.subject Multidisciplinary Sciences
dc.subject Wide Patterns
dc.subject Association
dc.subject Coral
dc.subject Transplant
dc.subject Climate
dc.subject Gene Expression
dc.title Role of gene body methylation in acclimatization and adaptation in a basal metazoan
dc.type journal article
dc.identifier.doi 10.1073/pnas.1813749115
dc.identifier.wos WOS:000454302600079

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