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Phylogeny Drives Large Scale Patterns in Australian Marine Bioactivity and Provides a New Chemical Ecology Rationale for Future Biodiscovery

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dc.contributor Western Australian Museum
dc.contributor Australian Institute Of Marine Science
dc.contributor Australian Inst Marine Sci LLEWELLYN, LYNDON EVANS-ILLIDGE, ELIZABETH A. LOGAN, MURRAY DOYLE, JASON FROMONT, JANE BATTERSHILL, CHRISTOPHER N. ERICSON, GAVIN WOLFF, CARSTEN W. MUIRHEAD, ANDREW KEARNS, PHILLIP ABDO, DAVID KININMONTH, STUART 2017-03-21T00:45:00Z 2013-10-18T02:43:56Z 2017-03-21T00:45:00Z 2019-10-21T21:40:32Z 2017-03-21T00:45:00Z 2017-03-21T00:45:00Z 2013-10-18T02:43:56Z 2019-10-21T21:40:32Z 2013-09-05
dc.identifier.citation Evans-Illidge EA, Logan M, Doyle J, Fromont J, Battershill CN, Ericson G, Wolff CW, Muirhead A, Kearns P, Abdo D, Kininmonth S, Llewellyn L (2013) Phylogeny drives large scale patterns in Australian marine bioactivity and provides a new chemical ecology rationale for future biodiscovery. PLoS ONE 8(9): e73800 en_US
dc.identifier.issn 1932-6203
dc.description.abstract 5 Twenty-five years of Australian marine bioresources collecting and research by the Australian Institute of Marine Science (AIMS) has explored the breadth of latitudinally and longitudinally diverse marine habitats that comprise Australia's ocean territory. The resulting AIMS Bioresources Library and associated relational database integrate biodiversity with bioactivity data, and these resources were mined to retrospectively assess biogeographic, taxonomic and phylogenetic patterns in cytotoxic, antimicrobial, and central nervous system (CNS)-protective bioactivity. While the bioassays used were originally chosen to be indicative of pharmaceutically relevant bioactivity, the results have qualified ecological relevance regarding secondary metabolism. In general, metazoan phyla along the deuterostome phylogenetic pathway (eg to Chordata) and their ancestors (eg Porifera and Cnidaria) had higher percentages of bioactive samples in the assays examined. While taxonomy at the phylum level and higher-order phylogeny groupings helped account for observed trends, taxonomy to genus did not resolve the trends any further. In addition, the results did not identify any biogeographic bioactivity hotspots that correlated with biodiversity hotspots. We conclude with a hypothesis that high-level phylogeny, and therefore the metabolic machinery available to an organism, is a major determinant of bioactivity, while habitat diversity and ecological circumstance are possible drivers in the activation of this machinery and bioactive secondary metabolism. This study supports the strategy of targeting phyla from the deuterostome lineage (including ancestral phyla) from biodiverse marine habitats and ecological niches, in future biodiscovery, at least that which is focused on vertebrate (including human) health.
dc.description.sponsorship The paper presents a collation and analysis of the results of a composite of research projects conducted over 25 years. During this time, funding has come primarily from the Australian Institute of Marine Science (government appropriation funding). Funding support was also provided from the US National Cancer Institute, the Western Australian Marine Science Institution, and the Australian biotechnology research and development company, AMRAD Corporation Ltd. No additional external funding was received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. en_US
dc.description.uri en_US
dc.language English
dc.language.iso en en_US
dc.publisher PLoS en_US
dc.relation.ispartof Null
dc.rights Attribution 3.0 Australia *
dc.rights.uri *
dc.subject Defense
dc.subject Continental-margin
dc.subject Paclitaxel
dc.subject Eleutherobin
dc.subject Sponges
dc.subject Scleractinian Corals
dc.subject Biodiversity Hotspots
dc.subject Natural-products
dc.subject Multidisciplinary Sciences
dc.subject Diversity
dc.subject Conservation
dc.subject Cytotoxic Macrolides
dc.subject Nitric-oxide Synthase
dc.subject Science & Technology - Other Topics
dc.subject Sponge Haliclona Sp
dc.title Phylogeny Drives Large Scale Patterns in Australian Marine Bioactivity and Provides a New Chemical Ecology Rationale for Future Biodiscovery
dc.type journal article en_US
dc.identifier.doi 10.1371/journal.pone.0073800
dc.identifier.wos WOS:000324481600101

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