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First report of saxitoxin in Finnish lakes and possible associated effects on human health

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dc.contributor Australian Institute Of Marine Science
dc.contributor Water Protect Assoc River Vantaa & Helsinki Regio
dc.contributor James Cook Univ N Queensland
dc.contributor Dept Biochem & Mol Biol
dc.contributor Natl Prod Control Agcy Welfare & Hlth
dc.contributor University Of Helsinki
dc.contributor Finnish Environment Institute
dc.contributor Helsinki Univ Hosp
dc.contributor James Cook University
dc.contributor Poison Informat Ctr
dc.contributor Helsinki University Central Hospital
dc.contributor Australian Inst Marine Sci
dc.contributor Finnish Environm Inst
dc.contributor Australian Institute Of Marine Science (aims) en LEPISTO, L RAPALA, J ROBERTSON, A NEGRI, AP BERG, KA TUOMI, P LYRA, C ERKOMAA, K LAHTI, K HOPPU, K 2017-03-21T01:10:19Z 2017-03-21T01:10:19Z 2013-02-28T06:49:12Z 2020-07-20T00:15:55Z 2017-03-21T01:10:19Z 2017-03-21T01:10:19Z 2013-02-28T06:49:12Z 2020-07-20T00:15:55Z 2005-06-01
dc.identifier 7002 en
dc.identifier.citation Rapala J, Robertson A, Negri AP, Berg KA, Tuomi P, Lyra C, Erkomaa K, Lahti K, Hoppu K and Lepisto L (2005) First report of saxitoxin in Finnish lakes and possible associated effects on human health. Environmental Toxicology. 20: 331-340. en
dc.identifier.issn 1520-4081
dc.description Link to abstract/full text - en
dc.description.abstract This study is the first report of saxitoxin in cyanobacterial blooms in Finland. Bloom samples (n = 50) were collected from Finnish freshwater sites during summer months of 2002 and 2003. These samples were screened for the presence of paralytic shellfish toxins (PSTs) using the Jellett rapid PSP screening test. Samples testing positive for PSTs (n = 7) were further analyzed with saxiphilin- and voltage-gated sodium channel [H-3]-STX-binding radioreceptor assays and liquid chromatography using fluorescence and mass spectrometric analysis. The results indicated that saxitoxin (STX) was the only PST analogue in the samples and that it was present in high concentrations, as much as 1 mg L-1. Microscopic analysis revealed that 95%-100% of the phytoplankton in the positive samples consisted of Anabaena lemmermannii. The trophic status of lakes in which STX-containing blooms were found varied from oligotrophic to hypertrophic. All the lakes had high nitrogen-to-phosphorus ratios. In some instances, samples had been collected from sites where swimmers had reported adverse health effects, and in three such cases, reported adverse health effects were associated with sites from which samples testing positive for STX had been received. Symptoms of fever, eye irritation, abdominal pains, and skin rash were reported in children aged 2-10 years after exposure to the water. These were not the adverse human symptoms typical of STX poisoning; rather, they represented acute effects often reported following recreational exposure to cyanobacterial blooms. (c) 2005 Wiley Periodicals, Inc.
dc.description.uri en
dc.language English
dc.language en en
dc.relation.ispartof Null
dc.relation.ispartof Environmental Toxicology - pages: 20: 331-340 en
dc.subject Saxiphilin
dc.subject Water Resources
dc.subject Sodium-channel
dc.subject Anabaena Lemmermannii
dc.subject Strains
dc.subject Receptor
dc.subject Environmental Sciences & Ecology
dc.subject Psp Toxins
dc.subject Environmental Sciences
dc.subject Adverse Health Effects
dc.subject Cyanobacteria
dc.subject Anabaena-circinalis
dc.subject Saxitoxin
dc.subject Fresh-water Cyanobacterium
dc.subject Purification
dc.subject Paralytic Shellfish Poisons
dc.subject Toxicology
dc.subject Aphanizomenon-flos-aquae
dc.title First report of saxitoxin in Finnish lakes and possible associated effects on human health
dc.type journal article en
dc.identifier.doi 10.1002/tox.20109
dc.identifier.wos WOS:000229897500017

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