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Biomedicinals from the phytosymbionts of marine invertebrates: A molecular approach

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dc.contributor Nci
dc.contributor Univ London
dc.contributor Nat Prod Branch
dc.contributor Dev Therapeut Program
dc.contributor Dept Chem
dc.contributor University Of Aberdeen
dc.contributor Nih National Cancer Institute (nci)
dc.contributor University College London
dc.contributor Univ Aberdeen
dc.contributor National Institutes Of Health (nih) - Usa
dc.contributor Sch Pharm
dc.contributor Australian Inst Marine Sci
dc.contributor University Of London
dc.contributor University Of London School Of Pharmacy
dc.contributor Australian Institute Of Marine Science
dc.contributor Australian Institute Of Marine Science (aims) en NEWMAN, DAVID J. DUNLAP, WALTER C. BATTERSHILL, CHRISTOPHER N. LIPTROT, CATHERINE H. COBB, ROSEMARY E. BOURNE, DAVID G. JASPARS, MARCEL LONG, PAUL F. 2013-02-28T06:42:41Z 2017-03-21T00:58:01Z 2017-03-21T00:58:01Z 2019-05-09T01:14:37Z 2013-02-28T06:42:41Z 2013-02-28T06:42:41Z 2017-03-21T00:58:01Z 2019-05-09T01:14:37Z 2007-08-01
dc.identifier 7492 en
dc.identifier.citation Dunlap WC, Battershill CN, Liptrot CH, Cobb RE, Bourne DG, Jaspars M, Long PF and Newman DJ (2007) Biomedicinals from the phytosymbionts of marine invertebrates: A molecular approach. Methods. 42: 358-376. en
dc.identifier.issn 1046-2023
dc.description Link to abstract/full text - en
dc.description.abstract Marine invertebrate animals such as sponges, gorgonians, tunicates and bryozoans are sources of biomedicinally relevant natural products, a small but growing number of which are advancing through clinical trials. Most metazoan and anthozoan species harbour commensal microorganisms that include prokaryotic bacteria, cyanobacteria (blue-green algae), eukaryotic microalgae, and fungi within host tissues where they reside as extra- and intra-cellular symbionts. In some sponges these associated microbes may constitute as much as 40% of the holobiont volume. There is now abundant evidence to suggest that a significant portion of the bioactive metabolites thought originally to be products of the source animal are often synthesized by their symbiotic microbiota. Several anti-cancer metabolites from marine sponges that have progressed to pre-clinical or clinical-trial phases, such as discodermolide, halichondrin B and bryostatin 1, are thought to be products derived from their microbiotic consortia. Freshwater and marine cyanobacteria are well recognised for producing numerous and structurally diverse bioactive and cytotoxic secondary metabolites suited to drug discovery. Sea sponges often contain dominant taxa-specific populations of cyanobacteria, and it is these phytosymbionts (= photosymbionts) that are considered to be the true biogenic source of a number of pharmacologically active polyketides and nonribosomally synthesized peptides produced within the sponge. Accordingly, new collections can be pre-screened in the field for the presence of phytobionts and, together with metagenomic screening using degenerate PCR primers to identify key polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) genes, afford a biodiscovery rationale based on the therapeutic prospects of phytochemical selection. Additionally, new cloning and biosynthetic expression strategies may provide a sustainable method for the supply of new pharmaceuticals derived from the uncultured phytosymbionts of marine organisms. (C) 2007 Elsevier Inc. All rights reserved.
dc.description.uri en
dc.language English
dc.language en en
dc.relation.ispartof Methods - pages: 42: 358-376 en
dc.relation.ispartof Null
dc.relation.uri en
dc.subject Selectively Inhibits 5-lipoxygenase
dc.subject Biomedicinals
dc.subject Nonribosomal Peptides
dc.subject Symbionts
dc.subject Biochemical Research Methods
dc.subject Natural-products
dc.subject Marine Natural Products
dc.subject Cyanobacteria
dc.subject Combinatorial Biosynthesis
dc.subject Heterologous Expression
dc.subject In-situ Hybridization
dc.subject Candidatus Endobugula Sertula
dc.subject Sponge Rhopaloeides Odorabile
dc.subject Ribosomal-rna Genes
dc.subject Polyketides
dc.subject Polyketide Synthase Genes
dc.subject Bacterial Symbionts
dc.subject Biochemistry & Molecular Biology
dc.subject Sponges
dc.subject New-zealand Sponge
dc.title Biomedicinals from the phytosymbionts of marine invertebrates: A molecular approach
dc.type journal article en
dc.identifier.doi 10.1016/j.ymeth.2007.03.001
dc.identifier.wos WOS:000247734000008

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