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Production of manoalide and its analogues by the sponge Luffariella variabilis is hardwired

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dc.contributor Australian Institute Of Marine Science
dc.contributor Aims & Jcu
dc.contributor Sch Marine & Trop Biol
dc.contributor James Cook Univ
dc.contributor James Cook University
dc.contributor Pmb 3
dc.contributor Sir George Fiher Bldg
dc.contributor Australian Inst Marine Sci
dc.contributor Australian Institute Of Marine Science (aims) en DE NYS, ROCKY ETTINGER-EPSTEIN, PIERS TAPIOLAS, DIANNE M. MOTTI, CHERIE A. WRIGHT, ANTHONY D. BATTERSHILL, CHRISTOPHER N. 2013-02-28T06:42:34Z 2013-02-28T06:42:34Z 2017-03-21T00:57:48Z 2019-07-08T02:13:40Z 2017-03-21T00:57:48Z 2017-03-21T00:57:48Z 2013-02-28T06:42:34Z 2019-07-08T02:13:40Z 2008-01-01
dc.identifier 7511 en
dc.identifier.citation Ettinger-Epstein P, Tapiolas DM, Motti CA, Wright AD, Battershill CN and de Nys R (2008) Production of manoalide and its analogues by the sponge Luffariella variabilis is hardwired. Marine Biotechnology. 10: 64-74. en
dc.identifier.issn 1436-2228
dc.description Link to abstract/full text - en
dc.description.abstract The Great Barrier Reef sponge Luffariella variabilis (Polejaeff 1884) produces a range of potent anti-inflammatory compounds as its major metabolites. These major metabolites-manoalide monoacetate, manoalide, luffariellin A and seco-manoalide-were monitored temporally and spatially to quantify the potential yield from wild harvest or aquaculture. Production of the major metabolites was hardwired at the population level with little variation in space and time over meters to tens of kilometers in the Palm Islands, Queensland, Australia. Manoalide monoacetate (35 to 70 mg g(-1) dry weight of sponge) was consistently the most abundant compound followed by manoalide (15 to 20 mg g(-1) dry weight). Luffariellin A and seco-manoalide were 10 to 70 times less abundant and varied between 0 and 3 mg g(-1) dry weight. On a larger spatial scale, L. variabilis from Davies Reef and Magnetic Island contained the same rank order and yields of compounds as the Palm Islands, indicating a generality of pattern over at least 100 km. The "hardwiring" of metabolite production at the population level by L. variabilis was also reflected in the lack of any inductive effect on metabolite production. In addition, individually monitored sponges produced fixed ratios of the major metabolites over time (years). However, these ratios varied between individuals, with some individuals consistently producing high levels of manoalide and manoalide monoacetate, providing the potential for selection of high-yielding stocks.
dc.description.uri en
dc.language English
dc.language en en
dc.relation.ispartof Marine Biotechnology - pages: 10: 64-74 en
dc.relation.ispartof Null
dc.subject Constitutive And Activated Defense
dc.subject Drug Discovery
dc.subject Biotechnology & Applied Microbiology
dc.subject Variation
dc.subject Alga
dc.subject Mycale-hentscheli
dc.subject Manoalide
dc.subject Secondary Metabolites
dc.subject Herbivory
dc.subject Marine Natural-products
dc.subject Activated Chemical Defense
dc.subject Marine & Freshwater Biology
dc.subject Delisea-pulchra
dc.subject Production
dc.subject Sponge
dc.subject Resistance
dc.subject Chemical Ecology
dc.subject Nutrient Availability
dc.title Production of manoalide and its analogues by the sponge Luffariella variabilis is hardwired
dc.type journal article en
dc.identifier.doi 10.1007/s10126-007-9037-x
dc.identifier.wos WOS:000252925500008

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