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Detailed NMR, Including 1,1-ADEQUATE, and Anticancer Studies of Compounds from the Echinoderm Colobometra perspinosa

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dc.contributor Australian Institute Of Marine Science
dc.contributor University Hawaii Hilo
dc.contributor Coll Pharm
dc.contributor University Of Hawaii System
dc.contributor Townsville Mc
dc.contributor Australian Inst Marine Sci
dc.contributor Univ Hawaii
dc.contributor Australian Institute Of Marine Science (aims) en
dc.contributor.author LIPTROT, CATHERINE H.
dc.contributor.author WRIGHT, ANTHONY D.
dc.contributor.author NIELSON, JONATHAN L.
dc.contributor.author TAPIOLAS, DIANNE M.
dc.contributor.author MOTTI, CHERIE A.
dc.contributor.author OVENDEN, SIMON P. B.
dc.contributor.author KEARNS, PHILIP S.
dc.date.accessioned 2017-03-21T00:51:13Z
dc.date.accessioned 2017-03-21T00:51:13Z
dc.date.accessioned 2013-02-28T06:45:47Z
dc.date.accessioned 2019-07-08T02:08:06Z
dc.date.available 2013-02-28T06:45:47Z
dc.date.available 2017-03-21T00:51:13Z
dc.date.available 2013-02-28T06:45:47Z
dc.date.available 2019-07-08T02:08:06Z
dc.date.issued 2009-12-01
dc.identifier 8337 en
dc.identifier.citation Wright AD, Nielson JL, Tapiolas DM, Motti CA, Ovenden SPB, Kearns P and Liptrot CH (2009) Detailed NMR, Including 1,1-ADEQUATE, and Anticancer Studies of Compounds from the Echinoderm Colobometra perspinosa. Marine Drugs. 7: 565-575. en
dc.identifier.issn 1660-3397
dc.identifier.uri http://epubs.aims.gov.au/11068/8337
dc.description Link to abstract/full text - http://dx.doi.org/10.3390/md7040565 en
dc.description.abstract From the dichloromethane/methanol extract of the crinoid Colobometra perspinosa, collected south east of Richards Island (Bedara), Family Islands, Central Great Barrier Reef, Australia, 3-(1'-hydroxypropyl)-1,6,8-trihydroxy-9,10-anthraquinone [one of the two stereoisomers of rhodoptilometrin, (1)], 3-propyl-1,6,8-trihydroxy-9,10-anthraquinone (3), 2-[(phenylacetyl)amino] ethanesulfonic acid (4), and 4-hydroxybutanoic acid (5) were isolated. Comparison of (1)H- and (13)C-NMR data for rhodoptilometrin (1) with those reported in the literature showed significant differences for some resonances associated with rings A and C. In an attempt to provide accurately assigned 1H- and (13)C-NMR data, as well as to confirm the structure of 1, a thorough NMR investigation of this compound was undertaken. Measurements included: concentration dependent (13)C, 1D selective NOE, HSQC, HMBC and 1,1-ADEQUATE. The NMR data for 4 and 5 are reported here for the first time, as is their occurrence from the marine environment. The in vitro anticancer activity of the original extract was found to be associated with 1, 3 and 5.
dc.description.uri http://dx.doi.org/10.3390/md7040565 en
dc.language English
dc.language en en
dc.relation.ispartof Null
dc.relation.ispartof Marine Drugs - pages: 7: 565-575 en
dc.subject Metabolites
dc.subject Gamma-hydroxybutyrate
dc.subject Ptilometra
dc.subject Marine Natural Products
dc.subject 1,1-adequate
dc.subject Echinoderm
dc.subject Colobometra Perspinosa
dc.subject Chemistry, Medicinal
dc.subject Anticancer
dc.subject Pharmacology & Pharmacy
dc.subject Nmr
dc.subject Pigments
dc.title Detailed NMR, Including 1,1-ADEQUATE, and Anticancer Studies of Compounds from the Echinoderm Colobometra perspinosa
dc.type journal article en
dc.identifier.doi 10.3390/md7040565
dc.identifier.wos WOS:000273042200007


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