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ESI FTICR-MS Analysis of Larvae from the Marine Sponge Luffariella variabilis

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dc.contributor Aims
dc.contributor Australian Institute Of Marine Science
dc.contributor Australian Inst Marine Sci
dc.contributor James Cook University
dc.contributor James Cook Univ
dc.contributor Sch Marine & Trop Biol
dc.contributor Australian Institute Of Marine Science (aims) en
dc.contributor.author WILLIS, RICHARD H.
dc.contributor.author TAPIOLAS, DIANNE M.
dc.contributor.author ETTINGER-EPSTEIN, PIERS
dc.contributor.author MOTTI, CHERIE A.
dc.date.accessioned 2017-03-21T00:50:32Z
dc.date.accessioned 2013-02-28T06:44:22Z
dc.date.accessioned 2013-02-28T06:44:22Z
dc.date.accessioned 2018-11-01T03:06:05Z
dc.date.available 2013-02-28T06:44:22Z
dc.date.available 2013-02-28T06:44:22Z
dc.date.available 2017-03-21T00:50:32Z
dc.date.available 2018-11-01T03:06:05Z
dc.date.issued 2010-01-01 en
dc.identifier 8414 en
dc.identifier.citation Motti CA, Ettinger-Epstein P, Willis RH and Tapiolas DM (2010) ESI FTICR-MS Analysis of Larvae from the Marine Sponge Luffariella variabilis. Marine Drugs. 8: 190-199. en
dc.identifier.issn 1660-3397
dc.identifier.uri http://epubs.aims.gov.au/11068/8414
dc.description Link to abstract/full text - http://dx.doi.org/10.3390/md8010190 en
dc.description.abstract The viviparous Great Barrier Reef sponge Luffariella variabilis (Polejaeff 1884) contains a range of secondary metabolites, including manoalide (1) and manoalide monoacetate (3). ESI (+) FTICR-MS accurate mass determination has, for the first time, been used to detected the presence of 3 only in an organic extract of a single L. variabilis larva showing that the parentally produced 3 is sequestered in the larva. As 3 has previously been shown to have antibacterial and quorum sensing inhibition activity, and readily converts to 1, which also exhibits similar activity, it may provide a chemical defence against predation and microbial attack.
dc.description.sponsorship Collection of the sponge and larvae was made possible by the access and benefit sharing arrangements between AIMS and the Australian Commonwealth Government (permit G05/11866.1) and by Rocky de Nys, James Cook University (permit G03/8695.1). The authors are grateful to P. Bergquist DBE, University of Auckland, for taxonomic identification of sponge materials. This work was supported by the Australian Research Advancement Program and the Great Barrier Reef Research Foundation.
dc.description.uri http://dx.doi.org/10.3390/md8010190 en
dc.language en en
dc.language English
dc.relation.ispartof Null
dc.relation.ispartof Marine Drugs - pages: 8: 190-199 en
dc.subject Manoalide Derivatives
dc.subject Pharmacology & Pharmacy
dc.subject Constitutive Defence
dc.subject Chemical Defenses
dc.subject Sesterterpenes
dc.subject Inactivation
dc.subject Chemistry, Medicinal
dc.subject Esi Fticr-ms
dc.subject Manoalide Monoacetate
dc.subject Venom Phospholipase-a2
dc.subject Red-sea
dc.subject Larvae
dc.subject Luffariella Variabilis
dc.title ESI FTICR-MS Analysis of Larvae from the Marine Sponge Luffariella variabilis
dc.type journal article en
dc.identifier.doi 10.3390/md8010190
dc.identifier.wos WOS:000273999600010


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